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Nicotine vs. Cocaine: Which Substance is More Addictive? How Big Tobacco Engineered Cigarettes to Be More Deadly and Addictive Than Ever Most Addictive Substances Ranked Nicotine is highly addictive and affects both the brain and body. Whether it's vaping or smoking, nicotine can lead to dependence, cravings, and serious health risks over time. Understanding how nicotine works
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